Research workbench
Crystal structure of prl-3 phosphatase in complex with the bateman domain of CNNM3 magnesium transporter
Analyse Crystal structure of prl-3 phosphatase in complex with the bateman domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TSR
- Type
- protein
- Length
- 605 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein tyrosine phosphatase type iva 3; Metal transporter CNNM3
- EC
- 3.1.3.48
- UniProt
- O75365, Q8NE01
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein tyrosine phosphatase type iva 3 (EC 3.1.3.48) | protein | 155 | 38% helix, 16% strand | O75365 |
| B | Metal transporter CNNM3 | protein | 149 | 36% helix, 27% strand | Q8NE01 |
| C | Protein tyrosine phosphatase type iva 3 (EC 3.1.3.48) | protein | 154 | 42% helix, 17% strand | O75365 |
| D | Metal transporter CNNM3 | protein | 147 | 36% helix, 27% strand | Q8NE01 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 568 | 0.65 | 0.76 | 57 | empty |
| 2 | 367 | 0.62 | 0.78 | 44 | empty |
| 3 | 108 | 0.59 | 0.85 | 20 | empty |
| 4 | 277 | 0.51 | 0.74 | 32 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1254 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 771 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 656 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5TSR · Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3… · the same entry in another collection · chain D against D, TM-score 1.00
- O75365 · AlphaFold monomer V2.0 prediction for protein tyrosine phosphatase type iva 3 (O75365) · a predicted model of the same protein · chain C against A, TM-score 0.97
- Q8NE01 · AlphaFold monomer V2.0 prediction for metal transporter CNNM3 (Q8NE01) · a predicted model of the same protein · chain D against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75365
- Every structure of UniProt Q8NE01
- Elsewhere: RCSB PDB 5TSR · PDBe 5TSR · UniProt O75365 · UniProt Q8NE01
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