Research workbench
Cryo-electron microscopy structure of a bovine clc-K chloride channel, main (class 1) conformation
Analyse Cryo-electron microscopy structure of a bovine clc-K chloride channel, main… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TQQ
- Type
- protein
- Length
- 1,642 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride channel protein; Monoclonal antibody, Fab fragment, light chain; Monoclonal…
- UniProt
- E1B792
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chloride channel protein | protein | 603 | 66% helix, 7% strand | E1B792 |
| L, M | Monoclonal antibody, Fab fragment, light chain | protein | 107 | 3% helix, 50% strand | — |
| H, I | Monoclonal antibody, Fab fragment, heavy chain | protein | 111 | 5% helix, 45% strand | — |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1003 | 0.81 | 0.82 | 95 | empty |
| 2 | 1035 | 0.79 | 0.80 | 112 | empty |
| 3 | 678 | 0.77 | 0.82 | 72 | empty |
| 4 | 256 | 0.69 | 0.85 | 44 | empty |
| 5 | 224 | 0.68 | 0.85 | 38 | empty |
Interfaces
8 interfaces between chains.
- A–B · 2818 Ų buried · 27 hydrogen bonds · protein-protein
- M–I · 828 Ų buried · 7 hydrogen bonds · protein-protein
- L–H · 822 Ų buried · 7 hydrogen bonds · protein-protein
- B–M · 651 Ų buried · 3 hydrogen bonds · protein-protein
- A–L · 640 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5TQQ · Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1B792
- Elsewhere: RCSB PDB 5TQQ · PDBe 5TQQ · UniProt E1B792
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