Research workbench
Crystal structure of assembly chaperone of ribosomal protein L4 (ACL4) in complex with ribosomal protein L4 (RPL4)
Analyse Crystal structure of assembly chaperone of ribosomal protein L4 (ACL4) in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TQB
- Type
- protein
- Length
- 580 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 60S ribosomal protein L4-like protein; Assembly chaperone of ribosomal protein L4 (ACL4)
- UniProt
- G0SFC3, G0S0I4
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 60S ribosomal protein L4-like protein | protein | 245 | 39% helix, 13% strand | G0SFC3 |
| B | Assembly chaperone of ribosomal protein L4 (ACL4) | protein | 335 | 74% helix, 0% strand | G0S0I4 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 8 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 344 | 0.74 | 0.85 | 44 | EDO |
| 2 | 308 | 0.63 | 0.79 | 27 | PEG |
| 3 | 174 | 0.58 | 0.81 | 28 | empty |
| 4 | 231 | 0.48 | 0.75 | 29 | EDO |
| 5 | 56 | 0.35 | 0.79 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3702 Ų buried · 55 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 5TQB · Crystal structure of assembly chaperone of ribosomal protein L4 (Acl4) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SFC3
- Every structure of UniProt G0S0I4
- Elsewhere: RCSB PDB 5TQB · PDBe 5TQB · UniProt G0SFC3 · UniProt G0S0I4
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