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Crystal structure of the marburg virus VP35 oligomerization domain P4222

Analyse Crystal structure of the marburg virus VP35 oligomerization domain P4222 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TOI
Type: protein
Length: 208 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase cofactor VP35
UniProt: P35259
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 94% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase cofactor VP35	protein	68	94% helix, 0% strand	P35259
B, C	Polymerase cofactor VP35	protein	70	94% helix, 0% strand	P35259

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.39	0.72	23	empty
2	95	0.36	0.75	19	empty

Interfaces

3 interfaces between chains.

A–C · 1083 Å² buried · 1 hydrogen bond · protein-protein
A–B · 1069 Å² buried · 2 hydrogen bonds · protein-protein
B–C · 749 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5TOI · Crystal Structure of the Marburg Virus VP35 Oligomerization Domain P4222 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35259
Elsewhere: RCSB PDB 5TOI · PDBe 5TOI · UniProt P35259

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