Research workbench
Crystal structure of H10 hemagglutinin mutant (K158AA-D193T-Q226L- G228S) from jiangxi-donghu (2013) H10N8 influenza virus
Analyse Crystal structure of H10 hemagglutinin mutant (K158AA-D193T-Q226L- G228S) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TGO
- Type
- protein
- Length
- 1,466 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin HA1 chain; Hemagglutinin HA2 chain
- UniProt
- A0A0J9X252, A0A0J9X253
- Ligands
- NAG, BMA, MAN
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 27% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Hemagglutinin HA1 chain | protein | 318 | 9% helix, 42% strand | A0A0J9X252 |
| B, F | Hemagglutinin HA2 chain | protein | 171 | 58% helix, 13% strand | A0A0J9X253 |
| C | Hemagglutinin HA1 chain | protein | 319 | 9% helix, 39% strand | A0A0J9X252 |
| D | Hemagglutinin HA2 chain | protein | 169 | 60% helix, 12% strand | A0A0J9X253 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains C, E, A, B, D
- BMA · beta-D-mannopyranose · sugar
- MAN · alpha-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.86 | 0.93 | 38 | empty |
| 2 | 1132 | 0.84 | 0.85 | 125 | empty |
| 3 | 85 | 0.74 | 0.96 | 22 | empty |
| 4 | 318 | 0.74 | 0.86 | 48 | empty |
| 5 | 81 | 0.73 | 0.96 | 20 | empty |
Interfaces
15 interfaces between chains.
- A–B · 3189 Ų buried · 45 hydrogen bonds · protein-protein
- C–D · 3166 Ų buried · 38 hydrogen bonds · protein-protein
- E–F · 3101 Ų buried · 43 hydrogen bonds · protein-protein
- D–F · 1528 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 1521 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 5TGO · Crystal structure of H10 hemagglutinin mutant (K158aA-D193T-Q226L-G228S) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0J9X252
- Every structure of UniProt A0A0J9X253
- Elsewhere: RCSB PDB 5TGO · PDBe 5TGO · UniProt A0A0J9X252 · UniProt A0A0J9X253
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.