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Human ubr-box from UBR2 in complex with hifs peptide

Analyse Human ubr-box from UBR2 in complex with hifs peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TDD
Type: protein
Length: 76 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase UBR2; His-ile-phe-ser peptide
EC: 6.3.2.-
UniProt: Q8IWV8
Ligands: ZN

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-)	protein	72	13% helix, 22% strand	Q8IWV8
B	His-ile-phe-ser peptide	protein	4	0% helix, 0% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 291 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5TDD · Human UBR-box from UBR2 in complex with HIFS peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q8IWV8 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase UBR2 (Q8IWV8) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IWV8
Elsewhere: RCSB PDB 5TDD · PDBe 5TDD · UniProt Q8IWV8

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