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Crystal structure of semet derivatives of DOMAIN2 and domain 3 of rctb

Analyse Crystal structure of semet derivatives of DOMAIN2 and domain 3 of rctb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TBF
Type: protein
Length: 553 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation elongation factor
UniProt: A0A0H5VUX2
Pockets: 7 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translation elongation factor	protein	280	35% helix, 32% strand	A0A0H5VUX2
B	Translation elongation factor	protein	273	36% helix, 30% strand	A0A0H5VUX2

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	191	0.60	0.82	33	empty
2	356	0.60	0.77	57	empty
3	230	0.59	0.80	30	empty
4	160	0.52	0.79	22	empty
5	91	0.36	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 2193 Å² buried · 48 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

5TBF · Crystal structure of SeMet derivatives of domain2 and domain 3 of RctB · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0H5VUX2
Elsewhere: RCSB PDB 5TBF · PDBe 5TBF · UniProt A0A0H5VUX2

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