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Structure of PCNA acetylated on K20

Analyse Structure of PCNA acetylated on K20 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5T9D
Type: protein
Length: 744 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen
UniProt: P15873
Pockets: 8 · best druggability 0.87

Structure

x-ray diffraction · 3 distinct chains · 21% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proliferating cell nuclear antigen	protein	249	22% helix, 44% strand	P15873
B	Proliferating cell nuclear antigen	protein	248	21% helix, 44% strand	P15873
C	Proliferating cell nuclear antigen	protein	247	21% helix, 43% strand	P15873

Pockets

8 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1145	0.87	0.88	139	empty
2	897	0.74	0.78	60	empty
3	51	0.73	0.98	16	empty
4	53	0.69	0.97	25	empty
5	57	0.67	0.95	21	empty

Interfaces

3 interfaces between chains.

B–C · 789 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 779 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 773 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5T9D · Structure of PCNA acetylated on K20 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15873
Elsewhere: RCSB PDB 5T9D · PDBe 5T9D · UniProt P15873

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