Research workbench

HLA-B*57:01 presenting sstrgisqlw

Analyse HLA-B*57:01 presenting sstrgisqlw in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5T6W
Type: protein
Length: 384 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HLA class I histocompatibility antigen, B-57 alpha chain; Beta-2-microglobulin…
UniProt: P18465, P61769
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	HLA class I histocompatibility antigen, B-57 alpha chain	protein	275	27% helix, 39% strand	P18465
B	Beta-2-microglobulin	protein	99	0% helix, 49% strand	P61769
C	Decapeptide: ser-ser-thr-arg-gly-ile-ser-gln-leu-TRP	protein	10	0% helix, 0% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	594	0.67	0.77	51	GOL
2	168	0.50	0.78	28	empty
3	78	0.39	0.78	14	empty

Interfaces

2 interfaces between chains.

A–B · 1376 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 941 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

5T6W · HLA-B*57:01 presenting SSTRGISQLW · the same entry in another collection · chain A against A, TM-score 1.00
P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18465
Every structure of UniProt P61769
Elsewhere: RCSB PDB 5T6W · PDBe 5T6W · UniProt P18465 · UniProt P61769

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