Research workbench
Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
Analyse Neisseria meningitidis factor H binding protein in complex with monoclonal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5T5F
- Type
- protein
- Length
- 654 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Factor H binding protein variant B24; Monoclonal antibody JAR5 heavy chain; Monoclonal…
- UniProt
- Q6VRZ6
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Factor H binding protein variant B24 | protein | 226 | 4% helix, 65% strand | Q6VRZ6 |
| H | Monoclonal antibody JAR5 heavy chain | protein | 212 | 9% helix, 54% strand | — |
| L | Monoclonal antibody JAR5 light chain | protein | 216 | 6% helix, 53% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 743 | 0.67 | 0.75 | 55 | empty |
| 2 | 87 | 0.40 | 0.78 | 23 | empty |
| 3 | 115 | 0.36 | 0.73 | 24 | empty |
| 4 | 58 | 0.33 | 0.77 | 15 | empty |
| 5 | 92 | 0.33 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1884 Ų buried · 16 hydrogen bonds · protein-protein
- A–H · 673 Ų buried · 17 hydrogen bonds · protein-protein
- A–L · 227 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5T5F · Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6VRZ6
- Elsewhere: RCSB PDB 5T5F · PDBe 5T5F · UniProt Q6VRZ6
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