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Lac repressor

Analyse Lac repressor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LBI
Type: protein
Length: 1,184 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lac repressor
UniProt: P03023
Pockets: 11 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Lac repressor	protein	296	43% helix, 18% strand	P03023

Pockets

11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	170	0.81	0.96	29	empty
2	477	0.76	0.84	66	empty
3	949	0.75	0.78	79	empty
4	262	0.75	0.88	46	empty
5	88	0.75	0.97	23	empty

Interfaces

6 interfaces between chains.

C–D · 2497 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 2301 Å² buried · 20 hydrogen bonds · protein-protein
B–D · 799 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 557 Å² buried · 1 hydrogen bond · protein-protein
A–D · 284 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1LBI · Lac repressor · the same entry in another collection · chain A against A, TM-score 1.00
P03023 · AlphaFold monomer V2.0 prediction for lactose operon repressor (P03023) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03023
Elsewhere: RCSB PDB 1LBI · PDBe 1LBI · UniProt P03023

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