Research workbench
Lactose operon repressor bound to 21-base pair symmetric operator DNA, alpha carbons only
Analyse Lactose operon repressor bound to 21-base pair symmetric operator DNA, alpha… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LBG
- Type
- protein + DNA
- Length
- 1,512 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP *TP*T)-3'); Protein…
- UniProt
- P03023
- Pockets
- 16 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F, G, H | DNA (5'- D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP *TP*T)-3') | dna | 21 | — | — |
| A, B, C, D | Protein (lactose operon repressor) | protein | 357 | 0% helix, 0% strand | P03023 |
Pockets
16 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.49 | 0.73 | 45 | empty |
| 2 | 213 | 0.47 | 0.74 | 39 | empty |
| 3 | 216 | 0.47 | 0.74 | 37 | empty |
| 4 | 138 | 0.44 | 0.76 | 19 | empty |
| 5 | 157 | 0.44 | 0.73 | 31 | empty |
Interfaces
14 interfaces between chains.
- G–H · 1142 Ų buried · 100 hydrogen bonds · nucleic-nucleic
- E–F · 945 Ų buried · 67 hydrogen bonds · nucleic-nucleic
- A–B · 329 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 317 Ų buried · 0 hydrogen bonds · protein-protein
- F–A · 273 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
- 1LBG · Lactose operon repressor bound to 21-base pair symmetric operator DNA, alpha carbons only · the same entry in another collection · chain C against C, TM-score 1.00
- P03023 · AlphaFold monomer V2.0 prediction for lactose operon repressor (P03023) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03023
- Elsewhere: RCSB PDB 1LBG · PDBe 1LBG · UniProt P03023
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