Research workbench

2A10 Fab fragment 2.54 angstoms

Analyse 2A10 Fab fragment 2.54 angstoms in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5SZF
Type: protein
Length: 429 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2A10 antibody Fab fragment light chain; 2A10 antibody Fab fragment heavy chain
Ligands: SO4
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	2A10 antibody Fab fragment light chain	protein	212	5% helix, 50% strand	—
H	2A10 antibody Fab fragment heavy chain	protein	217	7% helix, 53% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	385	0.56	0.74	61	empty
2	148	0.45	0.76	23	empty
3	97	0.37	0.75	17	empty

Interfaces

1 interface between chains.

L–H · 1927 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5SZF · 2A10 FAB fragment 2.54 Angstoms · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5SZF · PDBe 5SZF

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