Research workbench
Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in complex with Z28290384
Analyse Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5SLM
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proofreading exoribonuclease NSP14
- EC
- 3.1.13.-
- UniProt
- P0DTD1
- Ligands
- WN1, ZN, PO4
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Proofreading exoribonuclease NSP14 (EC 3.1.13.-) | protein | 461 | 29% helix, 21% strand | P0DTD1 |
Ligands and binding sites
- WN1 · N-(2-fluorophenyl)-3-methoxybenzamide · ligand · chains D
- ZN · Zinc ion · metal · 3 copies · chains D
- PO4 · Phosphate ion · ion · 2 copies · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.69 | 0.80 | 39 | empty |
| 2 | 200 | 0.48 | 0.75 | 30 | empty |
| 3 | 64 | 0.43 | 0.82 | 15 | WN1 |
| 4 | 72 | 0.38 | 0.78 | 22 | PO4 |
| 5 | 67 | 0.33 | 0.76 | 13 | empty |
Compared structures
- 5SLM · PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 5SLM · PDBe 5SLM · UniProt P0DTD1
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