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The domain-swapped dimer of cv-N in solution

Analyse The domain-swapped dimer of cv-N in solution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1L5E
Type: protein
Length: 202 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cyanovirin-N
UniProt: P81180
Pockets: 2 · best druggability 0.31

Structure

solution nmr · 1 distinct chain · 7% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cyanovirin-N	protein	101	7% helix, 57% strand	P81180

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.31	0.74	18	empty
2	52	0.28	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 3392 Å² buried · 63 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1L5E · The domain-swapped dimer of CV-N in solution · the same entry in another collection · chain A against A, TM-score 1.00
P81180 · AlphaFold monomer V2.0 prediction for cyanovirin-N (P81180) · a predicted model of the same protein · chain A against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P81180
Elsewhere: RCSB PDB 1L5E · PDBe 1L5E · UniProt P81180

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