Research workbench
MT0146, the precorrin-6Y methyltransferase (cbit) homolog from M. thermoautotrophicum, C2 spacegroup with short cell
Analyse MT0146, the precorrin-6Y methyltransferase (cbit) homolog from M.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1L3C
- Type
- protein
- Length
- 744 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Precorrin-6Y METHYLTRANSFERASE/PUTATIVE decarboxylase
- UniProt
- O26249
- Pockets
- 11 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Precorrin-6Y METHYLTRANSFERASE/PUTATIVE decarboxylase | protein | 186 | 34% helix, 32% strand | O26249 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 461 | 0.67 | 0.79 | 55 | empty |
| 2 | 394 | 0.67 | 0.80 | 53 | empty |
| 3 | 51 | 0.67 | 0.97 | 28 | empty |
| 4 | 404 | 0.65 | 0.79 | 47 | empty |
| 5 | 413 | 0.65 | 0.78 | 52 | empty |
Interfaces
6 interfaces between chains.
- A–D · 861 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 824 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 732 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 702 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 378 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
- 1L3C · MT0146, the precorrin-6Y methyltransferase (cbit) homolog from M. thermoautotrophicum, C2… · the same entry in another collection · chain D against D, TM-score 1.00
- O26249 · AlphaFold monomer V2.0 prediction for probable cobalt-precorrin-6B… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26249
- Elsewhere: RCSB PDB 1L3C · PDBe 1L3C · UniProt O26249
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.