Research workbench
Orotidine 5'-monophosphate decarboxylase from E. COLI
Analyse Orotidine 5'-monophosphate decarboxylase from E. COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1L2U
- Type
- protein
- Length
- 447 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orotidine 5'-phosphate decarboxylase
- EC
- 4.1.1.23
- UniProt
- P08244
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 224 | 51% helix, 17% strand | P08244 |
| B | Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) | protein | 223 | 51% helix, 17% strand | P08244 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.77 | 0.98 | 26 | empty |
| 2 | 318 | 0.61 | 0.79 | 42 | empty |
| 3 | 276 | 0.61 | 0.79 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 1913 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 1L2U · Orotidine 5'-monophosphate decarboxylase from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
- P08244 · AlphaFold monomer V2.0 prediction for orotidine 5'-phosphate decarboxylase (P08244) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08244
- Elsewhere: RCSB PDB 1L2U · PDBe 1L2U · UniProt P08244
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