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Crystal structure of aprtase from giardia lamblia complexed with 9- deazaadenine, MG2+ and prpp

Analyse Crystal structure of aprtase from giardia lamblia complexed with 9… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1L1R
Type: protein
Length: 179 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenine phosphoribosyltransferase
EC: 2.4.2.7
UniProt: Q967M2
Ligands: 9DA, PRP, MG
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adenine phosphoribosyltransferase (EC 2.4.2.7)	protein	179	36% helix, 32% strand	Q967M2

Ligands and binding sites

9DA · 9-deazaadenine · ligand · chains A
PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	195	0.68	0.86	28	MG, 9DA, PRP

Compared structures

1L1R · Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine, Mg2+ and… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q967M2
Elsewhere: RCSB PDB 1L1R · PDBe 1L1R · UniProt Q967M2

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