Research workbench
Pandda analysis group deposition -- crystal structure of SP100 after initial refinement with no ligand modelled (structure 16)
Analyse Pandda analysis group deposition -- crystal structure of SP100 after initial… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5PWS
- Type
- protein
- Length
- 355 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear autoantigen sp-100
- UniProt
- P23497
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear autoantigen sp-100 | protein | 178 | 50% helix, 6% strand | P23497 |
| B | Nuclear autoantigen sp-100 | protein | 177 | 49% helix, 6% strand | P23497 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.64 | 0.78 | 48 | MES, EDO |
| 2 | 99 | 0.35 | 0.74 | 15 | empty |
| 3 | 82 | 0.32 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 534 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5PWS · PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23497
- Elsewhere: RCSB PDB 5PWS · PDBe 5PWS · UniProt P23497
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