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Crystal structure of the protease domain of an ATP- independent heat shock protease htra
Analyse Crystal structure of the protease domain of an ATP- independent heat shock… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1L1J
- Type
- protein
- Length
- 452 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protease htra
- EC
- 3.4.21.-
- UniProt
- Q9WZ41
- Pockets
- 5 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heat shock protease htra (EC 3.4.21.-) | protein | 226 | 19% helix, 37% strand | Q9WZ41 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.44 | 0.76 | 19 | empty |
| 2 | 65 | 0.35 | 0.77 | 14 | empty |
| 3 | 55 | 0.31 | 0.76 | 16 | empty |
| 4 | 58 | 0.30 | 0.75 | 21 | empty |
| 5 | 52 | 0.29 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 477 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1L1J · Crystal structure of the protease domain of an ATP-independent heat shock protease HtrA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZ41
- Elsewhere: RCSB PDB 1L1J · PDBe 1L1J · UniProt Q9WZ41
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