Research workbench
Fmdv A10 dissociated pentamer
Analyse Fmdv A10 dissociated pentamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5OYI
- Type
- protein
- Length
- 2,820 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03306
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 9% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, A, D, G, J | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 161 | 8% helix, 29% strand | P03306 |
| 2, B, E, H, K | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 182 | 10% helix, 26% strand | P03306 |
| 3, C, F, I, L | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 221 | 10% helix, 13% strand | P03306 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1179 | 0.79 | 0.81 | 133 | empty |
| 2 | 899 | 0.79 | 0.81 | 98 | empty |
| 3 | 879 | 0.78 | 0.81 | 91 | empty |
| 4 | 651 | 0.78 | 0.83 | 77 | empty |
| 5 | 835 | 0.77 | 0.81 | 84 | empty |
Interfaces
52 interfaces between chains.
- J–L · 2558 Ų buried · 30 hydrogen bonds · protein-protein
- A–C · 2555 Ų buried · 30 hydrogen bonds · protein-protein
- D–F · 2547 Ų buried · 30 hydrogen bonds · protein-protein
- 1–3 · 2546 Ų buried · 30 hydrogen bonds · protein-protein
- G–I · 2544 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 5OYI · FMDV A10 dissociated pentamer · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03306
- Elsewhere: RCSB PDB 5OYI · PDBe 5OYI · UniProt P03306
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