Research workbench
KAP95:NUP1 complex
Analyse KAP95:NUP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5OWU
- Type
- protein
- Length
- 889 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-1; Nucleoporin NUP1
- UniProt
- Q06142, P20676
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-1 | protein | 860 | 80% helix, 0% strand | Q06142 |
| B | Nucleoporin NUP1 | protein | 29 | 14% helix, 0% strand | P20676 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.61 | 0.80 | 25 | empty |
| 2 | 147 | 0.45 | 0.77 | 25 | empty |
| 3 | 53 | 0.41 | 0.81 | 12 | empty |
| 4 | 69 | 0.39 | 0.79 | 20 | empty |
| 5 | 79 | 0.35 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1111 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5OWU · Kap95:Nup1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q06142 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q06142) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P20676 · AlphaFold monomer V2.0 prediction for nucleoporin NUP1 (P20676) · a predicted model of the same protein · chain B against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06142
- Every structure of UniProt P20676
- Elsewhere: RCSB PDB 5OWU · PDBe 5OWU · UniProt Q06142 · UniProt P20676
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