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Structure of TGPLP1 macpf domain

Analyse Structure of TGPLP1 macpf domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5OWN
Type: protein
Length: 586 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Perforin-like protein 1
UniProt: G3G7T1
Ligands: NAG
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Perforin-like protein 1	protein	295	36% helix, 29% strand	G3G7T1
B	Perforin-like protein 1	protein	291	36% helix, 29% strand	G3G7T1

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	830	0.79	0.82	92	empty
2	121	0.62	0.86	25	empty
3	172	0.49	0.77	23	empty
4	94	0.33	0.73	20	empty
5	67	0.32	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 971 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

5OWN · Structure of TgPLP1 MACPF domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3G7T1
Elsewhere: RCSB PDB 5OWN · PDBe 5OWN · UniProt G3G7T1

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