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P60P80-camsap complex

Analyse P60P80-camsap complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5OW5
Type: protein
Length: 504 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Katanin P80 WD40 repeat-containing subunit B1; Katanin P60 ATPase-containing subunit A1…
EC: 3.6.4.3
UniProt: Q8BG40, E9PZI6
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 5 distinct chains · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Katanin P80 WD40 repeat-containing subunit B1	protein	170	78% helix, 0% strand	Q8BG40
B	Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3)	protein	77	83% helix, 0% strand	E9PZI6
C	Katanin P80 WD40 repeat-containing subunit B1	protein	165	80% helix, 0% strand	Q8BG40
D	Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3)	protein	72	88% helix, 0% strand	E9PZI6
E, F	Calmodulin-regulated spectrin-associated protein	protein	10	80% helix, 0% strand	—

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains D
PEG · Di(hydroxyethyl)ether · additive · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	301	0.52	0.74	37	PEG
2	240	0.47	0.73	29	empty
3	79	0.34	0.75	16	empty
4	75	0.33	0.75	15	empty
5	75	0.31	0.73	14	empty

Interfaces

8 interfaces between chains.

A–B · 1577 Å² buried · 19 hydrogen bonds · protein-protein
C–D · 1484 Å² buried · 23 hydrogen bonds · protein-protein
A–D · 430 Å² buried · 5 hydrogen bonds · protein-protein
A–E · 347 Å² buried · 4 hydrogen bonds · protein-protein
C–F · 325 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5OW5 · p60p80-CAMSAP complex · the same entry in another collection · chain F against F, TM-score 1.00
Q8BG40 · AlphaFold monomer V2.0 prediction for katanin P80 WD40 repeat- containing subunit B1… · a predicted model of the same protein · chain C against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BG40
Every structure of UniProt E9PZI6
Elsewhere: RCSB PDB 5OW5 · PDBe 5OW5 · UniProt Q8BG40 · UniProt E9PZI6

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