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Crystal structure of the forkhead domain of human FOXN1

Analyse Crystal structure of the forkhead domain of human FOXN1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5OCN
Type: protein
Length: 664 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Forkhead box protein N1
UniProt: O15353
Ligands: K
Pockets: 7 · best druggability 0.68

Structure

x-ray diffraction · 7 distinct chains · 58% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Forkhead box protein N1	protein	86	58% helix, 13% strand	O15353
B	Forkhead box protein N1	protein	87	57% helix, 14% strand	O15353
C	Forkhead box protein N1	protein	83	60% helix, 13% strand	O15353
D	Forkhead box protein N1	protein	82	55% helix, 13% strand	O15353
E	Forkhead box protein N1	protein	82	59% helix, 15% strand	O15353
F	Forkhead box protein N1	protein	84	56% helix, 13% strand	O15353
G, H	Forkhead box protein N1	protein	80	59% helix, 14% strand	O15353

Ligands and binding sites

K · Potassium ion · metal · 8 copies · chains A, C, B, D, E, F, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	346	0.68	0.81	45	empty
2	250	0.66	0.83	37	empty
3	251	0.64	0.82	33	empty
4	81	0.51	0.84	19	empty
5	78	0.50	0.84	19	empty

Interfaces

7 interfaces between chains.

A–C · 879 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 821 Å² buried · 14 hydrogen bonds · protein-protein
G–H · 767 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 755 Å² buried · 13 hydrogen bonds · protein-protein
F–H · 554 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5OCN · Crystal structure of the forkhead domain of human FOXN1 · the same entry in another collection · chain H against H, TM-score 1.00
O15353 · AlphaFold monomer V2.0 prediction for forkhead box protein N1 (O15353) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15353
Elsewhere: RCSB PDB 5OCN · PDBe 5OCN · UniProt O15353

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