Research workbench
Crystal structure of mammalian REV7 in complex with REV3 1875-1895
Analyse Crystal structure of mammalian REV7 in complex with REV3 1875-1895 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5O8K
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; DNA polymerase zeta catalytic subunit
- EC
- 2.7.7.7
- UniProt
- Q9D752, O60673
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 203 | 32% helix, 29% strand | Q9D752 |
| B | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) | protein | 21 | 38% helix, 19% strand | O60673 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.35 | 0.75 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1112 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5O8K · Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9D752 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9D752
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 5O8K · PDBe 5O8K · UniProt Q9D752 · UniProt O60673
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