Research workbench
Structural genomics, protein TM1243, (saicar synthetase)
Analyse Structural genomics, protein TM1243, (saicar synthetase) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KUT
- Type
- protein
- Length
- 435 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylaminoimidazole-succinocarboxamide synthase
- EC
- 6.3.2.6
- UniProt
- Q9X0X0
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) | protein | 213 | 37% helix, 30% strand | Q9X0X0 |
| B | Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) | protein | 222 | 35% helix, 31% strand | Q9X0X0 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 819 | 0.71 | 0.76 | 80 | empty |
| 2 | 140 | 0.58 | 0.83 | 25 | empty |
| 3 | 252 | 0.53 | 0.76 | 25 | empty |
| 4 | 90 | 0.32 | 0.73 | 17 | empty |
| 5 | 56 | 0.32 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 969 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 1KUT · Structural Genomics, Protein TM1243, (SAICAR synthetase) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9X0X0 · AlphaFold monomer V2.0 prediction for phosphoribosylaminoimidazole- succinocarboxamide… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0X0
- Elsewhere: RCSB PDB 1KUT · PDBe 1KUT · UniProt Q9X0X0
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