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A disulfide switch determines proteolytic resistance in the birch pollen allergen bet V 2

Analyse A disulfide switch determines proteolytic resistance in the birch pollen… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NZC
Type: protein
Length: 247 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Profilin-2
UniProt: A4K9Z8
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Profilin-2	protein	124	30% helix, 35% strand	A4K9Z8
B	Profilin-2	protein	123	30% helix, 34% strand	A4K9Z8

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	304	0.56	0.76	34	empty
2	75	0.35	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 352 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5NZC · A disulfide switch determines proteolytic resistance in the birch pollen allergen Bet v 2 · the same entry in another collection · chain A against A, TM-score 1.00
A4K9Z8 · AlphaFold monomer V2.0 prediction for profilin-2 (A4K9Z8) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A4K9Z8
Elsewhere: RCSB PDB 5NZC · PDBe 5NZC · UniProt A4K9Z8

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