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Crystal structure of the anti-his tag antibody 3D5 single-chain fragment (scfv) in complex with a oligohistidine peptide

Analyse Crystal structure of the anti-his tag antibody 3D5 single-chain fragment (scfv)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KTR
Type: protein
Length: 233 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-his tag antibody 3D5 variable light chain, peptide linker, anti-his tag antibody 3D5…
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Anti-his tag antibody 3D5 variable light chain, peptide linker, anti-his tag antibody 3D5 variable heavy chain	protein	229	5% helix, 50% strand	—
P	Oligohistidine peptide antigen	protein	4	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.36	0.73	26	empty
2	75	0.34	0.75	18	empty

Interfaces

1 interface between chains.

L–P · 384 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1KTR · Crystal Structure of the Anti-His Tag Antibody 3D5 Single-Chain Fragment (scFv) in… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1KTR · PDBe 1KTR

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