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Structure of non-fluorescent human plasma RBP4

Analyse Structure of non-fluorescent human plasma RBP4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NTY
Type: protein
Length: 174 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinol-binding protein 4
UniProt: P02753
Ligands: PLM, CL
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinol-binding protein 4	protein	174	11% helix, 48% strand	P02753

Ligands and binding sites

PLM · Palmitic acid · ligand · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.83	0.97	27	PLM
2	64	0.32	0.75	13	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

5NTY · Structure of non-fluorescent human plasma RBP4 · the same entry in another collection · chain A against A, TM-score 1.00
P02753 · AlphaFold monomer V2.0 prediction for retinol-binding protein 4 (P02753) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02753
Elsewhere: RCSB PDB 5NTY · PDBe 5NTY · UniProt P02753

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