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Apo structure of leucyl aminopeptidase from trypanosoma cruzi

Analyse Apo structure of leucyl aminopeptidase from trypanosoma cruzi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NTF
Type: protein
Length: 1,024 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase
UniProt: V5BWE3
Ligands: SO4
Pockets: 8 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Aminopeptidase	protein	512	38% helix, 22% strand	V5BWE3

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	203	0.63	0.83	33	empty
2	187	0.62	0.84	40	empty
3	359	0.62	0.78	34	SO4
4	205	0.60	0.81	21	empty
5	312	0.59	0.77	38	SO4

Interfaces

1 interface between chains.

A–B · 1499 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

5NTF · apo Structure of Leucyl aminopeptidase from Trypanosoma cruzi · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt V5BWE3
Elsewhere: RCSB PDB 5NTF · PDBe 5NTF · UniProt V5BWE3

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