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X-ray structure of der P 2, the major house dust mite allergen

Analyse X-ray structure of der P 2, the major house dust mite allergen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1KTJ
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Allergen der P 2
UniProt: P49278
Pockets: 4 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Allergen der P 2	protein	129	2% helix, 53% strand	P49278

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	510	0.86	0.92	58	empty
2	518	0.85	0.90	57	empty
3	59	0.37	0.79	19	empty
4	55	0.33	0.78	19	empty

Interfaces

1 interface between chains.

A–B · 694 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1KTJ · X-ray Structure Of Der P 2, The Major House Dust Mite Allergen · the same entry in another collection · chain A against A, TM-score 1.00
P49278 · AlphaFold monomer V2.0 prediction for mite group 2 allergen der P 2 (P49278) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49278
Elsewhere: RCSB PDB 1KTJ · PDBe 1KTJ · UniProt P49278

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