Research workbench

Structure of a FHBP(V1.1):PORA(P1.16) chimera. fusion at fhbp position 294.

Analyse Structure of a FHBP(V1.1):PORA(P1.16) chimera. fusion at fhbp position 294. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NQX
Type: protein
Length: 1,257 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Factor H binding PROTEIN,MAJOR outer membrane protein P.IA, factor H binding protein
UniProt: Q9JXV4, P13415
Pockets: 14 · best druggability 0.59

Structure

x-ray diffraction · 4 distinct chains · 6% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Factor H binding PROTEIN,MAJOR outer membrane protein P.IA, factor H binding protein	protein	250	6% helix, 60% strand	Q9JXV4, P13415
A, D	Factor H binding PROTEIN,MAJOR outer membrane protein P.IA, factor H binding protein	protein	255	6% helix, 61% strand	Q9JXV4, P13415
B	Factor H binding PROTEIN,MAJOR outer membrane protein P.IA, factor H binding protein	protein	247	6% helix, 61% strand	Q9JXV4, P13415
E	Factor H binding PROTEIN,MAJOR outer membrane protein P.IA, factor H binding protein	protein	250	6% helix, 62% strand	Q9JXV4, P13415

Pockets

14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	491	0.59	0.74	57	empty
2	146	0.50	0.79	19	empty
3	145	0.40	0.74	24	empty
4	97	0.38	0.76	17	empty
5	74	0.37	0.78	15	empty

Interfaces

6 interfaces between chains.

A–E · 916 Å² buried · 19 hydrogen bonds · protein-protein
C–D · 583 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 556 Å² buried · 9 hydrogen bonds · protein-protein
C–E · 193 Å² buried · 0 hydrogen bonds · protein-protein
D–E · 171 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5NQX · Structure of a fHbp(V1.1):PorA(P1.16) chimera. Fusion at fHbp position 294. · the same entry in another collection · chain E against E, TM-score 1.00
P13415 · AlphaFold monomer V2.0 prediction for major outer membrane protein P.IA (P13415) · a predicted model of the same protein · chain A against A, TM-score 0.35

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JXV4
Every structure of UniProt P13415
Elsewhere: RCSB PDB 5NQX · PDBe 5NQX · UniProt Q9JXV4 · UniProt P13415

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.