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Crystal structure of plasmodium falciparum AMA1 in complex with a 39 aa PVRON2 peptide

Analyse Crystal structure of plasmodium falciparum AMA1 in complex with a 39 aa PVRON2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NQF
Type: protein
Length: 333 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apical membrane antigen 1; Rhoptry neck protein 2
UniProt: A0A024UZE1, A5K3N8
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 16% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apical membrane antigen 1	protein	298	16% helix, 30% strand	A0A024UZE1
B	Rhoptry neck protein 2	protein	35	17% helix, 23% strand	A5K3N8

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.47	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 1532 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5NQF · Crystal structure of Plasmodium falciparum AMA1 in complex with a 39 aa PvRON2 peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt A0A024UZE1
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Elsewhere: RCSB PDB 5NQF · PDBe 5NQF · UniProt A0A024UZE1 · UniProt A5K3N8

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