Research workbench
Neutron structure of human transthyretin (ttr) T119M mutant at room temperature to 1.85A resolution
Analyse Neutron structure of human transthyretin (ttr) T119M mutant at room temperature… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NFE
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction; neutron diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Pockets
- 3 · best druggability 0.35
Structure
x-ray diffraction; neutron diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 116 | 6% helix, 53% strand | P02766 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.35 | 0.76 | 15 | empty |
| 2 | 55 | 0.32 | 0.77 | 14 | empty |
| 3 | 52 | 0.25 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 929 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5NFE · Neutron structure of human transthyretin (TTR) T119M mutant at room temperature to 1.85A… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 5NFE · PDBe 5NFE · UniProt P02766
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