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Antiparallel monomeric coiled coil of KIF21A

Analyse Antiparallel monomeric coiled coil of KIF21A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NFD
Type: protein
Length: 153 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinesin-like protein KIF21A
UniProt: Q7Z4S6
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kinesin-like protein KIF21A	protein	75	91% helix, 0% strand	Q7Z4S6
B	Kinesin-like protein KIF21A	protein	78	91% helix, 0% strand	Q7Z4S6

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.71	0.97	20	empty
2	81	0.50	0.84	15	empty

Interfaces

1 interface between chains.

A–B · 1340 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5NFD · Antiparallel monomeric coiled coil of Kif21A · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z4S6 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF21A (Q7Z4S6) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z4S6
Elsewhere: RCSB PDB 5NFD · PDBe 5NFD · UniProt Q7Z4S6

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