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Crystal structure of H60A H307A mutant of thermotoga maritima TMPEP1050 aminopeptidase

Analyse Crystal structure of H60A H307A mutant of thermotoga maritima TMPEP1050… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NE9
Type: protein
Length: 616 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase
EC: 3.4.11.1
UniProt: Q9X0E0
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aminopeptidase (EC 3.4.11.1)	protein	306	25% helix, 29% strand	Q9X0E0
B	Aminopeptidase (EC 3.4.11.1)	protein	310	27% helix, 28% strand	Q9X0E0

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	328	0.59	0.77	51	empty
2	275	0.56	0.77	40	empty
3	215	0.47	0.74	29	empty
4	180	0.45	0.75	25	empty

Interfaces

1 interface between chains.

A–B · 564 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5NE9 · Crystal structure of H60A H307A mutant of Thermotoga maritima TmPEP1050 aminopeptidase · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X0E0
Elsewhere: RCSB PDB 5NE9 · PDBe 5NE9 · UniProt Q9X0E0

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