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Crystal structure of H307A mutant of thermotoga maritima TMPEP1050 aminopeptidase

Analyse Crystal structure of H307A mutant of thermotoga maritima TMPEP1050… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5NE8
Type: protein
Length: 617 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase
EC: 3.4.11.1
UniProt: Q9X0E0
Pockets: 2 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aminopeptidase (EC 3.4.11.1)	protein	309	27% helix, 31% strand	Q9X0E0
B	Aminopeptidase (EC 3.4.11.1)	protein	308	28% helix, 31% strand	Q9X0E0

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	407	0.62	0.77	66	empty
2	52	0.25	0.73	12	empty

Interfaces

1 interface between chains.

A–B · 551 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5NE8 · Crystal structure of H307A mutant of Thermotoga maritima TmPEP1050 aminopeptidase · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X0E0
Elsewhere: RCSB PDB 5NE8 · PDBe 5NE8 · UniProt Q9X0E0

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