Research workbench
Structure of the trypsin induced serpin-type proteinase inhibitor, miropin.
Analyse Structure of the trypsin induced serpin-type proteinase inhibitor, miropin. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NCT
- Type
- protein
- Length
- 363 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serpin-type proteinase inhibitor, miropin
- UniProt
- G8UQY8
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serpin-type proteinase inhibitor, miropin | protein | 327 | 31% helix, 36% strand | G8UQY8 |
| C | Serpin-type proteinase inhibitor, miropin | protein | 36 | 0% helix, 53% strand | G8UQY8 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 184 | 0.65 | 0.84 | 23 | empty |
| 2 | 58 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 2577 Ų buried · 46 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5NCT · Structure of the trypsin induced serpin-type proteinase inhibitor, miropin. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8UQY8
- Elsewhere: RCSB PDB 5NCT · PDBe 5NCT · UniProt G8UQY8
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