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Crystal structure of drosophila DHX36 helicase in complex with polyu

Analyse Crystal structure of drosophila DHX36 helicase in complex with polyu in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5N94
Type: protein + RNA
Length: 1,714 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CG9323, isoform a; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*U)-3')
EC: 3.6.1.3
UniProt: Q8SWT2
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CG9323, isoform a (EC 3.6.1.3)	protein	849	46% helix, 15% strand	Q8SWT2
C, D	RNA (5'-R(PUPUPUPUPUPUPUPU)-3')	rna	8	—	—

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	785	0.87	0.90	77	empty
2	714	0.86	0.90	74	empty
3	304	0.79	0.90	38	empty
4	257	0.77	0.90	32	empty
5	204	0.72	0.88	29	empty

Interfaces

3 interfaces between chains.

A–C · 1358 Å² buried · 28 hydrogen bonds · protein-nucleic
B–D · 1340 Å² buried · 26 hydrogen bonds · protein-nucleic
A–B · 468 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5N94 · Crystal Structure of Drosophila DHX36 helicase in complex with polyU · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8SWT2
Elsewhere: RCSB PDB 5N94 · PDBe 5N94 · UniProt Q8SWT2

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