Research workbench
Crystal structure of the coiled-coil domain of human tricellulin
Analyse Crystal structure of the coiled-coil domain of human tricellulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5N7K
- Type
- protein
- Length
- 442 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Marvel domain-containing protein 2
- UniProt
- Q8N4S9
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Marvel domain-containing protein 2 | protein | 106 | 84% helix, 0% strand | Q8N4S9 |
| B | Marvel domain-containing protein 2 | protein | 115 | 85% helix, 1% strand | Q8N4S9 |
| C | Marvel domain-containing protein 2 | protein | 107 | 84% helix, 0% strand | Q8N4S9 |
| D | Marvel domain-containing protein 2 | protein | 114 | 82% helix, 1% strand | Q8N4S9 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.77 | 0.90 | 28 | empty |
| 2 | 274 | 0.65 | 0.82 | 28 | empty |
| 3 | 241 | 0.47 | 0.73 | 29 | empty |
| 4 | 76 | 0.40 | 0.78 | 20 | empty |
| 5 | 52 | 0.37 | 0.79 | 11 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1069 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 918 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 890 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 93 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 53 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5N7K · Crystal structure of the coiled-coil domain of human tricellulin · the same entry in another collection · chain D against D, TM-score 1.00
- Q8N4S9 · AlphaFold monomer V2.0 prediction for marvel domain-containing protein 2 (Q8N4S9) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N4S9
- Elsewhere: RCSB PDB 5N7K · PDBe 5N7K · UniProt Q8N4S9
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