Research workbench
Crystal structure of the cytosolic domain of the cora magnesium channel from escherichia COLI in complex with magnesium
Analyse Crystal structure of the cytosolic domain of the cora magnesium channel from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5N77
- Type
- protein
- Length
- 1,280 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Magnesium transport protein cora
- UniProt
- P0ABI4
- Ligands
- MG
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Magnesium transport protein cora | protein | 257 | 58% helix, 18% strand | P0ABI4 |
| C | Magnesium transport protein cora | protein | 254 | 57% helix, 19% strand | P0ABI4 |
| E | Magnesium transport protein cora | protein | 255 | 58% helix, 18% strand | P0ABI4 |
Ligands and binding sites
- MG · Magnesium ion · metal · 7 copies · chains A, B, C, D, E
- PG0 · 2-(2-methoxyethoxy)ethanol · additive · 3 copies · chains A, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 808 | 0.74 | 0.79 | 54 | MG |
| 2 | 303 | 0.62 | 0.79 | 26 | empty |
| 3 | 272 | 0.61 | 0.80 | 24 | empty |
| 4 | 296 | 0.61 | 0.79 | 26 | empty |
| 5 | 292 | 0.60 | 0.79 | 27 | empty |
Interfaces
10 interfaces between chains.
- D–E · 1612 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1599 Ų buried · 25 hydrogen bonds · protein-protein
- B–E · 1572 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 1556 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 1527 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 5N77 · Crystal structure of the cytosolic domain of the CorA magnesium channel from Escherichia… · the same entry in another collection · chain E against E, TM-score 1.00
- P0ABI4 · AlphaFold monomer V2.0 prediction for magnesium transport protein cora (P0ABI4) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ABI4
- Elsewhere: RCSB PDB 5N77 · PDBe 5N77 · UniProt P0ABI4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.