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Crystal structure of SRPK2 in complex with compound 1

Analyse Crystal structure of SRPK2 in complex with compound 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MYV
Type: protein
Length: 1,400 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P78362
Ligands: W4A, SO4

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	352	—	P78362
B	—	protein	349	—	P78362
C	—	protein	348	—	P78362
D	—	protein	351	—	P78362

Ligands and binding sites

W4A · 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide · ligand · 4 copies · chains A, B, C, D
SO4 · Sulfate ion · ion · 48 copies · chains A, B, C, D
DMS · Dimethyl sulfoxide · additive · 3 copies · chains A, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5MYV · Crystal structure of SRPK2 in complex with compound 1 · the same entry in another collection · chain D against D, TM-score 1.00
P78362 · AlphaFold monomer V2.0 prediction for srsf protein kinase 2 (P78362) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78362
Elsewhere: RCSB PDB 5MYV · PDBe 5MYV · UniProt P78362

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