Research workbench
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from M. musculus in complex with IP6
Analyse Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from M. musculus in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MWM
- Type
- protein
- Length
- 407 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol-pentakisphosphate 2-kinase
- EC
- 2.7.1.158
- UniProt
- Q6P1C1
- Ligands
- IHP, ZN
- Pockets
- 5 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) | protein | 407 | 42% helix, 14% strand | Q6P1C1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1036 | 0.82 | 0.83 | 110 | IHP |
| 2 | 70 | 0.52 | 0.86 | 19 | empty |
| 3 | 172 | 0.51 | 0.78 | 32 | empty |
| 4 | 64 | 0.41 | 0.80 | 11 | empty |
| 5 | 53 | 0.29 | 0.75 | 14 | empty |
Compared structures
- 5MWM · Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from M. musculus in complex with IP6 · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P1C1 · AlphaFold monomer V2.0 prediction for inositol-pentakisphosphate 2-kinase (Q6P1C1) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P1C1
- Elsewhere: RCSB PDB 5MWM · PDBe 5MWM · UniProt Q6P1C1
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