Research workbench
Crystal structure of CTF19-MCM21 kinetochore assembly bound with CTF19-MCM21 binding motif of central kinetochore subunit OKP1
Analyse Crystal structure of CTF19-MCM21 kinetochore assembly bound with CTF19-MCM21… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MU3
- Type
- protein
- Length
- 745 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Central kinetochore subunit MCM21; Central kinetochore subunit CTF19; Central kinetochore…
- UniProt
- Q6CVQ9, Q6CRN7, Q6CJY0
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 37% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Central kinetochore subunit MCM21 | protein | 184 | 28% helix, 37% strand | Q6CVQ9 |
| B | Central kinetochore subunit CTF19 | protein | 163 | 46% helix, 31% strand | Q6CRN7 |
| C | Central kinetochore subunit OKP1 | protein | 24 | 42% helix, 4% strand | Q6CJY0 |
| D | Central kinetochore subunit MCM21 | protein | 185 | 30% helix, 37% strand | Q6CVQ9 |
| E | Central kinetochore subunit CTF19 | protein | 164 | 45% helix, 27% strand | Q6CRN7 |
| F | Central kinetochore subunit OKP1 | protein | 25 | 40% helix, 8% strand | Q6CJY0 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 595 | 0.73 | 0.81 | 70 | empty |
| 2 | 216 | 0.67 | 0.84 | 31 | empty |
| 3 | 515 | 0.66 | 0.77 | 48 | empty |
| 4 | 140 | 0.43 | 0.75 | 23 | empty |
| 5 | 153 | 0.42 | 0.74 | 22 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1660 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 1648 Ų buried · 21 hydrogen bonds · protein-protein
- E–F · 903 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 869 Ų buried · 12 hydrogen bonds · protein-protein
- B–E · 525 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 5MU3 · Crystal structure of Ctf19-Mcm21 kinetochore assembly bound with Ctf19-Mcm21 binding… · the same entry in another collection · chain F against F, TM-score 1.00
- Q6CRN7 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit CTF19 (Q6CRN7) · a predicted model of the same protein · chain E against A, TM-score 0.99
- Q6CVQ9 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM21 (Q6CVQ9) · a predicted model of the same protein · chain D against A, TM-score 0.99
- Q6CJY0 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit OKP1 (Q6CJY0) · a predicted model of the same protein · chain F against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6CVQ9
- Every structure of UniProt Q6CRN7
- Every structure of UniProt Q6CJY0
- Elsewhere: RCSB PDB 5MU3 · PDBe 5MU3 · UniProt Q6CVQ9 · UniProt Q6CRN7 · UniProt Q6CJY0
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