Research workbench

Mouse PA28BETA

Analyse Mouse PA28BETA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MSK
Type: protein
Length: 1,451 residues
Chains: 7
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome activator complex subunit 2
UniProt: P97372
Pockets: 20 · best druggability 0.72

Structure

x-ray diffraction · 7 distinct chains · 76% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proteasome activator complex subunit 2	protein	210	75% helix, 1% strand	P97372
B	Proteasome activator complex subunit 2	protein	211	75% helix, 1% strand	P97372
C	Proteasome activator complex subunit 2	protein	206	76% helix, 1% strand	P97372
D	Proteasome activator complex subunit 2	protein	207	76% helix, 1% strand	P97372
E	Proteasome activator complex subunit 2	protein	201	76% helix, 1% strand	P97372
F	Proteasome activator complex subunit 2	protein	208	76% helix, 1% strand	P97372
G	Proteasome activator complex subunit 2	protein	208	75% helix, 1% strand	P97372

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	515	0.72	0.81	60	empty
2	512	0.70	0.80	59	empty
3	500	0.70	0.80	62	empty
4	488	0.70	0.80	64	empty
5	487	0.70	0.80	62	empty

Interfaces

7 interfaces between chains.

C–D · 2235 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 2183 Å² buried · 15 hydrogen bonds · protein-protein
E–F · 2108 Å² buried · 19 hydrogen bonds · protein-protein
A–G · 2079 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 2011 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

5MSK · Mouse PA28beta · the same entry in another collection · chain G against G, TM-score 1.00
P97372 · AlphaFold monomer V2.0 prediction for proteasome activator complex subunit 2 (P97372) · a predicted model of the same protein · chain E against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97372
Elsewhere: RCSB PDB 5MSK · PDBe 5MSK · UniProt P97372

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