Research workbench
Mouse PA28ALPHA
Analyse Mouse PA28ALPHA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MSJ
- Type
- protein
- Length
- 5,723 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome activator complex subunit 1
- UniProt
- P97371
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 28 distinct chains · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proteasome activator complex subunit 1 | protein | 210 | 75% helix, 1% strand | P97371 |
| B | Proteasome activator complex subunit 1 | protein | 204 | 76% helix, 1% strand | P97371 |
| C | Proteasome activator complex subunit 1 | protein | 205 | 77% helix, 1% strand | P97371 |
| D | Proteasome activator complex subunit 1 | protein | 203 | 78% helix, 1% strand | P97371 |
| E | Proteasome activator complex subunit 1 | protein | 208 | 75% helix, 1% strand | P97371 |
| F | Proteasome activator complex subunit 1 | protein | 201 | 78% helix, 1% strand | P97371 |
| G | Proteasome activator complex subunit 1 | protein | 205 | 76% helix, 1% strand | P97371 |
| H | Proteasome activator complex subunit 1 | protein | 208 | 76% helix, 1% strand | P97371 |
| I | Proteasome activator complex subunit 1 | protein | 195 | 81% helix, 1% strand | P97371 |
| J | Proteasome activator complex subunit 1 | protein | 202 | 77% helix, 0% strand | P97371 |
| K | Proteasome activator complex subunit 1 | protein | 207 | 75% helix, 1% strand | P97371 |
| L | Proteasome activator complex subunit 1 | protein | 209 | 73% helix, 1% strand | P97371 |
| M | Proteasome activator complex subunit 1 | protein | 201 | 77% helix, 1% strand | P97371 |
| N | Proteasome activator complex subunit 1 | protein | 208 | 75% helix, 1% strand | P97371 |
| O | Proteasome activator complex subunit 1 | protein | 203 | 77% helix, 1% strand | P97371 |
| P | Proteasome activator complex subunit 1 | protein | 208 | 77% helix, 1% strand | P97371 |
| Q | Proteasome activator complex subunit 1 | protein | 203 | 77% helix, 1% strand | P97371 |
| R | Proteasome activator complex subunit 1 | protein | 200 | 78% helix, 1% strand | P97371 |
| S | Proteasome activator complex subunit 1 | protein | 199 | 78% helix, 1% strand | P97371 |
| T | Proteasome activator complex subunit 1 | protein | 206 | 75% helix, 1% strand | P97371 |
| U | Proteasome activator complex subunit 1 | protein | 212 | 78% helix, 1% strand | P97371 |
| V | Proteasome activator complex subunit 1 | protein | 202 | 76% helix, 1% strand | P97371 |
| W | Proteasome activator complex subunit 1 | protein | 204 | 79% helix, 1% strand | P97371 |
| X | Proteasome activator complex subunit 1 | protein | 200 | 77% helix, 2% strand | P97371 |
| Y | Proteasome activator complex subunit 1 | protein | 201 | 78% helix, 1% strand | P97371 |
| Z | Proteasome activator complex subunit 1 | protein | 204 | 77% helix, 1% strand | P97371 |
| a | Proteasome activator complex subunit 1 | protein | 209 | 75% helix, 1% strand | P97371 |
| b | Proteasome activator complex subunit 1 | protein | 206 | 78% helix, 1% strand | P97371 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 553 | 0.77 | 0.84 | 72 | empty |
| 2 | 538 | 0.77 | 0.84 | 67 | empty |
| 3 | 567 | 0.76 | 0.83 | 66 | empty |
| 4 | 538 | 0.75 | 0.83 | 69 | empty |
| 5 | 468 | 0.75 | 0.84 | 63 | empty |
Interfaces
62 interfaces between chains.
- D–E · 2280 Ų buried · 24 hydrogen bonds · protein-protein
- J–K · 2228 Ų buried · 24 hydrogen bonds · protein-protein
- K–L · 2214 Ų buried · 20 hydrogen bonds · protein-protein
- M–N · 2205 Ų buried · 19 hydrogen bonds · protein-protein
- a–b · 2205 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 5MSJ · Mouse PA28alpha · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97371
- Elsewhere: RCSB PDB 5MSJ · PDBe 5MSJ · UniProt P97371
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