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Ligand-receptor complex.

Analyse Ligand-receptor complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5MR9
Type: protein
Length: 200 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurturin
UniProt: Q99748
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurturin	protein	99	15% helix, 39% strand	Q99748
B	Neurturin	protein	101	15% helix, 40% strand	Q99748

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.38	0.77	19	empty
2	51	0.35	0.80	14	empty

Interfaces

1 interface between chains.

A–B · 2141 Å² buried · 35 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

5MR9 · Ligand-receptor complex. · the same entry in another collection · chain A against A, TM-score 1.00
Q99748 · AlphaFold monomer V2.0 prediction for neurturin (Q99748) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99748
Elsewhere: RCSB PDB 5MR9 · PDBe 5MR9 · UniProt Q99748

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