Research workbench
Crystal structure of the clc chloride channel from E. COLI
Analyse Crystal structure of the clc chloride channel from E. COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KPK
- Type
- protein
- Length
- 2,700 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative channel transporter
- UniProt
- P37019
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Putative channel transporter | protein | 450 | 68% helix, 0% strand | P37019 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 583 | 0.85 | 0.90 | 58 | empty |
| 2 | 595 | 0.85 | 0.90 | 56 | empty |
| 3 | 590 | 0.85 | 0.89 | 54 | empty |
| 4 | 349 | 0.70 | 0.83 | 30 | empty |
| 5 | 362 | 0.69 | 0.82 | 28 | empty |
Interfaces
3 interfaces between chains.
- C–D · 3639 Ų buried · 31 hydrogen bonds · protein-protein
- A–B · 3638 Ų buried · 31 hydrogen bonds · protein-protein
- E–F · 3621 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 1KPK · Crystal Structure of the ClC Chloride Channel from E. coli · the same entry in another collection · chain F against F, TM-score 1.00
- P37019 · AlphaFold monomer V2.0 prediction for H(+)/CL(-) exchange transporter clca (P37019) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37019
- Elsewhere: RCSB PDB 1KPK · PDBe 1KPK · UniProt P37019
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