Research workbench
Biotin dependent carboxylase ACCA3 dimer from mycobacterium tuberculosis (RV3285)
Analyse Biotin dependent carboxylase ACCA3 dimer from mycobacterium tuberculosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MLK
- Type
- protein
- Length
- 835 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl-CoA carboxylase
- UniProt
- P96890
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl-CoA carboxylase | protein | 451 | 34% helix, 25% strand | P96890 |
| B | Acetyl-CoA carboxylase | protein | 384 | 33% helix, 25% strand | P96890 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 490 | 0.75 | 0.83 | 49 | empty |
| 2 | 659 | 0.72 | 0.79 | 78 | empty |
| 3 | 268 | 0.67 | 0.83 | 61 | empty |
| 4 | 306 | 0.56 | 0.76 | 42 | empty |
| 5 | 64 | 0.53 | 0.88 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1283 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 5MLK · Biotin dependent carboxylase AccA3 dimer from Mycobacterium tuberculosis (Rv3285) · the same entry in another collection · chain A against A, TM-score 1.00
- P96890 · AlphaFold monomer V2.0 prediction for biotin-dependent acyl-coenzyme a carboxylase ALPHA3… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96890
- Elsewhere: RCSB PDB 5MLK · PDBe 5MLK · UniProt P96890
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